Triethylamine → (2-Bromo-3-pyridyl)methyl methanesulfonate
反応式
C(N(CC)CC)C.[Br:8][C:9]1[C:14]([CH2:15][OH:16])=[CH:13][CH:12]=[CH:11][N:10]=1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[CH3:17][S:18]([O:16][CH2:15][C:14]1[C:9]([Br:8])=[N:10][CH:11]=[CH:12][CH:13]=1)(=[O:20])=[O:19]参加物
5
実験手順
Triethylamine (8.90 mL) is added to a round bottom flask containing a solution of (2-bromopyridin-3-yl)methanol (8 g, 42.55 mmol) in dichloromethane (212 mL) at 0° C., then methanesulfonyl chloride (3.95 mL) is added and the mixture is stirred at that temperature for 1.5 h. After that time the mixture is washed with water and organic layer is decanted, dried over magnesium sulfate and solvent evaporated under reduced pressure to yield 10.4 g of the title compound used without further purification. MS (m/z): 266, 268 (M+1; M+3).
後処理
- washAfter that time the mixture is washed with water and organic layer
- customis decanted
- dry with materialdried over magnesium sulfate and solvent
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-593bcd02dce941f9b453c909b64faf74
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08232289B2
反応ノート
読み込み中…