Ethanol → 2-(2-Bromopyridin-3-yl)acetonitrile

HRID 1517581ノート

反応式

HRID 1517581 の反応式
[Br:1][C:2]1[C:7]([CH2:8]Br)=[CH:6][CH:5]=[CH:4][N:3]=1.[C-:10]#[N:11].[Na+].O.C(O)C>ClCCl>[Br:1][C:2]1[C:7]([CH2:8][C:10]#[N:11])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 702EthanolHCID 962WaterHCID 8929Sodium CyanideHCID 109010782-Bromo-3-(bromomethyl)pyridine

生成物 1

HCID 534035092-(2-Bromopyridin-3-yl)acetonitrile収率 83%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 2-bromo-3-bromomethyl-pyridine (840 mg, 3.35 mmol) and sodium cyanide (187.99 mg, 3.68 mmol) is stirred and refluxed for 1 h in a mixture water (10 mL)-ethanol (2 mL). The reaction mixture is diluted with dichloromethane and washed with saturated aqueous solution of sodium bicarbonate. The organic layer is separated, dried over magnesium sulfate and the solvent evaporated in vacuo to give 83% of the title compound that is used without further purification. MS (m/z): 197 (M+1), 199 (M+3).

後処理

  1. washwashed with saturated aqueous solution of sodium bicarbonate
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulfate
  4. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-259963ad65984f20a3e2916a844a5af0
出典データセット
uspto-grants-2012_07
特許番号
US08232289B2

反応ノート

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