N-Hydroxy-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylamide → HCID 11348242、化合物

HRID 1517774ノート

反応式

HRID 1517774 の反応式
ONC(=O)C=CC1C=CN(S(CC2C=CC=CC=2)(=O)=O)C=1.[CH3:22][N:23]([CH3:50])[C:24]1[CH:29]=[CH:28][C:27]([S:30]([N:33]2[CH:37]=[CH:36][C:35](/[CH:38]=[CH:39]/[C:40]([NH:42][O:43]C3CCCCO3)=[O:41])=[CH:34]2)(=[O:32])=[O:31])=[CH:26][CH:25]=1>CO.O>[CH3:50][N:23]([CH3:22])[C:24]1[CH:25]=[CH:26][C:27]([S:30]([N:33]2[CH:37]=[CH:36][C:35](/[CH:38]=[CH:39]/[C:40]([NH:42][OH:43])=[O:41])=[CH:34]2)(=[O:31])=[O:32])=[CH:28][CH:29]=1

参加物

4

反応物 2

HCID 73069393N-Hydroxy-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylamideHCID 86613976HCID 86613976、化合物2 回

生成物 1

HCID 11348242HCID 11348242、化合物

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

The method used for preparation of this compound is analogous to the method described for compound 2. Starting materials: (E)-3-[1-(4-dimethylamino-benzene sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (compound A4) (0.200 g), methanol/water 3/2 (50 ml), amberlyst IR15 (0.402 g). Reaction conditions: room temperature, 34 hours.

後処理

  1. customThe method used for preparation of this compound
  2. customReaction conditions
  3. customroom temperature, 34 hours

出典と根拠

ORDレコード
ord-33ed5f2924e640fb87790c350413ed91
出典データセット
uspto-grants-2012_07
特許番号
US08232297B2

反応ノート

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