Potassium Hydroxide → N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

HRID 1517876ノート

反応式

HRID 1517876 の反応式
C([O:4][C:5]1([CH2:8][O:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14]([O:20][C:21]4[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]5[C:31](=[O:43])[N:32]([C:37]6[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=6)[N:33]([CH3:36])[C:34]=5[CH3:35])=[O:29])=[CH:23][C:22]=4[F:44])=[CH:15][CH:16]=[N:17]3)=[CH:12][CH:11]=2)[CH2:7][CH2:6]1)(=O)C.[OH-].[K+]>CO>[F:44][C:22]1[CH:23]=[C:24]([NH:27][C:28]([C:30]2[C:31](=[O:43])[N:32]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[N:33]([CH3:36])[C:34]=2[CH3:35])=[O:29])[CH:25]=[CH:26][C:21]=1[O:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([O:9][CH2:8][C:5]3([OH:4])[CH2:6][CH2:7]3)=[CH:11][CH:12]=2)[N:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 66684940HCID 66684940、化合物

生成物 1

HCID 66670625N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide収率 100.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of compounds 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl acetate (110 mg, 0.18 mmol) in 8 mL of methanol was added KOH (100 mg, 1.78 mmol) slowly. After stirring at rt for 0.5 hr, the reaction mixture was filtered and the solid was washed with ethyl acetate (10 mL×2) to give the title compound as a white solid (100 mg, 29%).

後処理

  1. filtrationthe reaction mixture was filtered
  2. washthe solid was washed with ethyl acetate (10 mL×2)

出典と根拠

ORDレコード
ord-00fd4e165355417eae1104d3a58a8bba
出典データセット
uspto-grants-2012_07
特許番号
US08232294B2

反応ノート

読み込み中…