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3,5-Bis(trifluoromethyl)benzaldehyde → 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Bis(trifluoromethyl)benzaldehyde | HCID 136247 | — |
| 反応物 | 1-methyl-1H-tetrazol-5-amine | HCID 138492 | — |
| 反応物 | 2-methyl-2H-1,2,3,4-tetrazol-5-amine | HCID 138677 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine | HCID 76645725 | — |
反応手順
A crude mixture of 5-amino-2-methyltetrazole and 5-amino-1-methyltetrazole is treated with 3,5-bis(trifluoromethyl)benzaldehyde (48 mL, 71 g, 0.29 mol) in toluene (780 mL), and the mixture is stirred and refluxed for 5 hours. The resulting mixture is filtered to remove off the insoluble solid (5-amino-1-methyltetrazole), and the residue is washed with hot toluene. The filtrate is concentrated to give crude 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine (70.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08232403B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-0ecfce2fee11470d9d89f56af0ea6374 |
| 出典メモ | uspto-grants-2012_07 |