Ammonia → 2-[4-(Bromomethyl)phenyl]acetamide
反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.C[N:14](C)C=O.C1(C)C=CC=CC=1.N>O>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([NH2:14])=[O:12])=[CH:5][CH:4]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
To a solution of (4-bromomethyl-phenyl)-acetic acid (9.23 g, 40.30 mmol) and N,N-dimethylformamide (0.5 ml, 6.47 mmol) in toluene (100 ml) thionyl chloride (3.1 ml, 42.31 mmol) was added. The mixture was heated at 80° C. for 1 h. At 0° C., this mixture was added to a solution of ammonia in water (25%, 200 ml). After stirring for 30 min the precipitate was collected, washed with water and pentane, and dried in a vacuum oven at 50° C. to give the product as white crystals (5.8 g, 63%).
後処理
- customwas collected
- washwashed with water and pentane
- customdried in a vacuum oven at 50° C.
出典と根拠
- ORDレコード
- ord-c26bc974a13d412d938d8d9159f17198
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08232426B2
反応ノート
読み込み中…