2-(Dimethylamino)ethanol → 2-(2-chloropyrimidin-5-yloxy)-N,N-dimethylethanamine

反応式

NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(O)=CC=2)C=1C#N.[CH3:23][N:24]([CH3:28])[CH2:25][CH2:26][OH:27].[Cl:29][C:30]1[N:35]=[CH:34][C:33](O)=[CH:32][N:31]=1>>[Cl:29][C:30]1[N:35]=[CH:34][C:33]([O:27][CH2:26][CH2:25][N:24]([CH3:28])[CH3:23])=[CH:32][N:31]=1

参加物

反応物 3

HCID 79022-(Dimethylamino)ethanol

HCID 145957002-Chloro-5-pyrimidinol

HCID 136027725tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate

生成物 1

HCID 594474952-(2-chloropyrimidin-5-yloxy)-N,N-dimethylethanamine

実験手順

Compound 112B was prepared in a similar manner to the synthesis of step 1 of Example 35 by substituting compound 34D and compound 31F with 2-(dimethylamino)ethanol and compound 112A, respectively: ESI (+)MS: 201 (M+H)−.

出典と根拠

ORDレコード: ord-a1eb909c926f4edcaf8e0c36d7162c66
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08232273B2

反応ノート

読み込み中…

参加物