Hydrochloric Acid → 4-(piperidin-4-yloxy)-1-(pyridin-3-yl)pyridin-2(1H)-one hydrochloric acid salt
反応式
[O:1]=[C:2]1[CH:7]=[C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:4][N:3]1[C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.[ClH:28]>CO>[ClH:28].[NH:12]1[CH2:11][CH2:10][CH:9]([O:8][C:6]2[CH:5]=[CH:4][N:3]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)[C:2](=[O:1])[CH:7]=2)[CH2:14][CH2:13]1参加物
4
実験手順
A mixture of tert-butyl 4-(2-oxo-1-(pyridin-3-yl)-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate (142 mg, 0.382 mmol), hydrogen chloride (4.0 M in 1,4-dioaxne, 1.5 mL, Aldrich) in MeOH (1.5 mL) was stirred at room temperature for 45 min and then concentrated to give the product (115 mg) as a light orange solid. The material was used in the next step without further purification. MS (ESI) 272 (M+H).