Hydrochloric Acid → 4-Bromo-2-phenylaniline
反応式
[C:1]1([C:7]2[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:8]=2[NH:9]C(=O)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)C>[C:1]1([C:7]2[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:8]=2[NH2:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
2-Phenyl-4-bromo-N-acetylaniline (7.79 g, 26.85 mmol) was dissolved in ethanol (100 mL), 2 N hydrochloric acid (33.56 mmol, 67.12 mL) was added dropwise under ice bath, and the mixture was heated under reflux overnight. The solution was concentrated under reduced pressure and to the residue were added ethyl acetate (50 mL) and water (40 mL) for extraction. The organic layer was dried over sodium sulfate and, after filtration, concentrated under reduced pressure. The residue was purified by a silica gel column to obtain 2-phenyl-4-bromoaniline (6.58 g).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux overnight
- concentrationThe solution was concentrated under reduced pressure and to the residue
- additionwere added ethyl acetate (50 mL) and water (40 mL)
- extractionfor extraction
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationafter filtration
- concentrationconcentrated under reduced pressure
- customThe residue was purified by a silica gel column
出典と根拠
- ORDレコード
- ord-2d5602354ea84c34b8c1ca9d286ce53d
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09072734B2
反応ノート
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