2-Bromo-1-(2,4-dimethylphenyl)ethanone → HCID 71537481、化合物
反応式
C[O:2][C:3]([C:5]1[C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-:22])=[O:21])=[CH:7][CH:8]=[C:9]([C:11](=[S:13])[NH2:12])[CH:10]=1)=[O:4].Br[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][C:28]=1[CH3:34])=O>>[CH3:34][C:28]1[CH:29]=[C:30]([CH3:33])[CH:31]=[CH:32][C:27]=1[C:25]1[N:12]=[C:11]([C:9]2[CH:10]=[C:5]([C:3]([OH:2])=[O:4])[C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N+:20]([O-:22])=[O:21])=[CH:7][CH:8]=2)[S:13][CH:24]=1参加物
3
実験手順
4-[4-(2,4-Dimethyl-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (126 mg, 47%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-bromo-1-(2,4-dimethylphenyl)ethan-1-one (available from ASDI Incorporated) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 8.52 (d, J=1.8 Hz, 1H), 8.10-8.18 (m, 2H), 7.85 (s, 1H), 7.76 (t, J=7.7 Hz, 1H), 7.11-7.40 (m, 4H), 2.48 (s, 3H), 2.34 (s, 3H).
後処理
- customdescribed for the preparation of Example 1