Hydrochloric Acid → 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:26][CH2:25][C:24]3[C:16](=[CH:17][C:18]4[C:19]([CH:23]=3)=[N:20][O:21][N:22]=4)[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[N:11]1([CH:14]2[CH2:26][CH2:25][C:24]3[C:16](=[CH:17][C:18]4[C:19]([CH:23]=3)=[N:20][O:21][N:22]=4)[CH2:15]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
To a flask charged with tert-Butyl-4-(5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazol-6-yl)piperazine-1-carboxylate (50 mg, 0.14 mmol) was added 4N HCl in dioxane (1 mL). The mixture was allowed to stir for 30 minutes at RT. LC showed complete reaction. The solvent was removed under reduced pressure, and the resulting 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride was used without further purification.