4'-Iodobiphenyl-4-carboxylic acid → 4-Iodo-4'-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}biphenyl

HRID 1519723ノート

反応式

HRID 1519723 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.[CH3:18][NH:19][C:20](=[O:28])[C@H:21]([C:24](=[O:27])[O:25][CH3:26])[NH:22][CH3:23]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14](=[O:16])[N:22]([CH:21]([C:20]([NH:19][CH3:18])=[O:28])[C:24]([O:25][CH3:26])=[O:27])[CH3:23])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 8167304'-Iodobiphenyl-4-carboxylic acidHCID 86679246N,N2,O-trimethyl-3-oxoserinamide hydrochloride2 回

生成物 1

HCID 712681754-Iodo-4'-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}biphenyl収率 58%

実験手順

Using 4′-iodobiphenyl-4-carboxylic acid (1.8 g) obtained by the same method as the synthesis method described in the literature (Zhurnal Organicheskoi Khimii, 1981, Vol. 17(12), pp. 2598-2601) and N,N2,O-trimethyl-3-oxoserinamide hydrochloride (Intermediate 5-2, 1.1 g), the same procedure as in Example 4-(4) was performed to obtain 4-iodo-4′-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}biphenyl (light yellow solid) (1.5 g, 58%).

後処理

  1. customobtained by the same method as the synthesis method

出典と根拠

ORDレコード
ord-f96640021ffd440794208de4672b4fcf
出典データセット
uspto-grants-2015_07
特許番号
US09073821B2

反応ノート

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