Dichloromethane → 2-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

HRID 1519847ノート

反応式

HRID 1519847 の反応式
[F:1][C:2]1([F:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C:3]1=[O:19].C(Cl)Cl>C(O)=O>[F:20][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([OH:14])=[O:13])[C:3]1=[O:19]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 68754561tert-Butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate

生成物 1

HCID 687551942-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A 30 mL reaction vial was charged with tert-butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate (275 mg, 1 mmol) as a yellow oil. DCM (3 mL) was added, followed by an equal volume of formic acid. The reaction was stirred for 16 h. The reaction mixture was concentrated under reduced pressure to give 2-(3,3-difluoro-2-oxoindolin-1-yl)acetic acid as a yellow solid. The desired M+H (228) was observed in the LCMS using the method [1] with a retention time of 1.652 min.

後処理

  1. customA 30 mL reaction
  2. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-dd22639bc42e46c08963effbada514bd
出典データセット
uspto-grants-2015_07
特許番号
US09073891B2

反応ノート

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