Hydrochloric Acid → 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid
反応式
Cl.[O:2]=[C:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[N:8][CH:9]=2)[N:4]1[CH2:13][C:14]([O:16]C)=[O:15]>C(O)(=O)C>[O:2]=[C:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[N:8][CH:9]=2)[N:4]1[CH2:13][C:14]([OH:16])=[O:15]参加物
4
反応条件
- 温度
- 60 °C
実験手順
Aqueous 1N HCl (2 mL) was added to a solution of methyl 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetate (1.24 g, 5.67 mmol) in acetic acid (5 mL) and the resulting mixture was heated to 60° C. for 4 h. The solution was concentrated under vacuum to give 2-(2-Oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid. Retention time (min)=0.275, method [1], MS(ESI) 207.0 (M+H).
後処理
- concentrationThe solution was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-03239bf592de43ac8f998c88cc38d75f
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073891B2
反応ノート
読み込み中…