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Monobenzone → (S)-Glycidyl-4-benzyloxyphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Monobenzone | HCID 7638 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (S)-Glycidyl-4-benzyloxyphenol | HCID 54047008 | — |
反応手順
A mixture of 4-benzyloxyphenol (2.0 g, 10 mMol) and potassium carbonate (4.14 g, 30 mMol) in acetone (50 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (2.23 g, 10 mMol) was added and the reaction mixture was heated under reflux for 18 hours. After cooling, the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726165 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-f128083fd7554ead9f40eeecd8845c28 |
| 出典メモ | uspto-grants-1998_03 |