Hydrochloric Acid → 4-(4-Nitrophenyl)-1,2,3,6-tetrahydropyridine hydrochloride
反応式
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:12][CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15][CH:16]=2)=[CH:7][CH:6]=1)([O-:4])=[O:3]>O1CCOCC1.C1(C)C=CC=CC=1>[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH:12]=2)=[CH:7][CH:6]=1)([O-:4])=[O:3]参加物
5
実験手順
Hydrogen chloride (20 mL of a 4N solution in dioxane) was added dropwise to a solution of tert-butyl 4-(4-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate (3.0 g; 9.86 mmol; 1.0 eq.) in toluene (15 mL). The reaction mixture was stirred at RT for 3 h. The formed suspension was filtered, washed with toluene (10 mL) and dried under vacuum to give the title compound as a white solid (1.96 g, 97%). UPLC/MS: (MS+) 205.3.
後処理
- filtrationThe formed suspension was filtered
- washwashed with toluene (10 mL)
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-c5cd66c1b5f24861a0e5cc9408c06220
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073892B2
反応ノート
読み込み中…