Dissolve 6-chloro-2-methylpyrimidine-4-carbonitrile (628 mg, 4.1 mmol) in DMF (15 mL) at RT under a nitrogen atmosphere. Add (4-hydroxyphenyl)methanesulfonamide (859 mg, 4.1 mmol) and potassium carbonate (1.13 g, 8.2 mmol) to the solution. Stir at ambient temperature for 3 hours. Pour the mixture into a brine solution, and extract with EtOAc. Combine the extracts; dry over magnesium sulfate; filter; and concentrate the filtrate under reduced pressure to provide the title compound (80% pure, 1.5 g, 96.4%). MS (m/z): 305 (M+1).
