Triethylamine → HCID 86695474、化合物
反応式
Cl.Cl.[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([NH2:13])[CH2:12][CH2:11]2)=[N:8][CH:9]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([NH:13][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:11][CH2:12]2)=[N:8][CH:9]=1参加物
5
実験手順
Commercially available 1-(5-bromopyridin-2-yl)cyclopropanamine dihydrochloric acid salt (494 mg, 1.73 mmol) is dissolved in CH2Cl2 (11.5 mL, 0.15M) and had 3.1 eq. of triethylamine (543 mg, 5.36 mmol) added to it. 1.1 eq. of methanesulfonyl chloride (218 mg, 1.9 mmol) is then added and the mixture stirred for 16 hours. Dichloromethane (20 mL) is added and washed with NaHCO3 (sat, aq). The solvent is evaporated to give the title compound (310 mg): m/z (Cl) 293 [M+H].
後処理
- additionadded to it
- washwashed with NaHCO3 (sat, aq)
- customThe solvent is evaporated
出典と根拠
- ORDレコード
- ord-c904a191ed504546bf07709161c43428
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073894B2
反応ノート
読み込み中…