Triethylamine → 1-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene

HRID 1520600ノート

反応式

HRID 1520600 の反応式
[F:1][C:2](I)([F:4])[F:3].[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13].C(N(CC)CC)C>CN(C)C=O.O>[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][C:2]([F:4])([F:3])[F:1]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 16843TrifluoroiodomethaneHCID 5202162-Fluorothiophenol

生成物 1

HCID 470028801-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Methyl viologen hydrochloride (1.17 g) in N,N-dimethylformamide (80 mL) at 25° C. was saturated with trifluoromethyl iodide, treated with 2-fluorobenzenethiol (9.7 mL) and triethylamine (20 mL), stirred for 24 hours, diluted with water (240 mL) and extracted with diethyl ether. The extract was washed with 1M NaOH, saturated ammonium chloride and brine and concentrated.

後処理

  1. customat 25° C.
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with 1M NaOH, saturated ammonium chloride and brine
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-575857cd3cc64ee8b43eb4eed9de8dc5
出典データセット
uspto-grants-2015_07
特許番号
US09073855B2

反応ノート

読み込み中…