Triethylamine → (R)-methyl 4-(1-(methylsulfonyloxy)butyl)benzoate

HRID 1520900ノート

反応式

HRID 1520900 の反応式
[OH:1][C@@H:2]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(OC)(C)(C)C>[CH3:23][S:24]([O:1][C@@H:2]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5])(=[O:26])=[O:25]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68157820(R)-methyl 4-(1-hydroxybutyl)benzoate

生成物 1

HCID 86669087(R)-methyl 4-(1-(methylsulfonyloxy)butyl)benzoate

試薬・触媒・溶媒 1

HCID 15413tert-Butyl methyl ether溶媒

実験手順

To a solution of (R)-methyl 4-(1-hydroxybutyl)benzoate, intermediate (26) (10 g, 48 mmol) in methyl t-butyl ether (80 mL) containing triethylamine (6.32 g, 62 mmol) was added methanesulfonyl chloride (6.05 g, 53 mmol) slowly at 20° C. The solution was filtered to remove triethylamine salts and the solution used in the next step without isolation.

後処理

  1. filtrationThe solution was filtered
  2. customto remove triethylamine salts

出典と根拠

ORDレコード
ord-dbffa96af5404644b88028ed6332670e
出典データセット
uspto-grants-2015_07
特許番号
US09073871B2

反応ノート

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