Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → (5-Methyl-3-pyridin-3-yl-isoxazol-4-yl)-methanol

HRID 1521139ノート

反応式

HRID 1521139 の反応式
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:8][O:9][C:10]=1[CH3:11])=O)C.C(OC(C1C(C2C=CC=C(F)C=2)=NOC=1C)=O)C>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[CH2:4][OH:3]

参加物

3

反応物 2

HCID 22309060Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylateHCID 22309064Ethyl 5-Methyl-3-(3-pyridyl)isoxazole-4-carboxylate

生成物 1

HCID 68442705(5-Methyl-3-pyridin-3-yl-isoxazol-4-yl)-methanol収率 67%

実験手順

As described for example 88d, 5-methyl-3-pyridin-3-yl-isoxazole-4-carboxylic acid ethyl ester (7.9 g, 34 mmol), instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, was converted, to the title compound (4.3 g, 67%) which was obtained as a light yellow liquid. MS: m/e=191.3 [M+H]+.

出典と根拠

ORDレコード
ord-ad9a789d7cf14aa3bf0a6ee87b4d72bd
出典データセット
uspto-grants-2015_07
特許番号
US09073908B2

反応ノート

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