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1,1,1-Trifluoro-2-propanamine → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1,1-Trifluoro-2-propanamine | HCID 3783165 | — |
| 反応物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 生成物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide | HCID 68445495 | 98% |
反応手順
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (150 mg, 0.45 mmol) was converted, using L-2,2,2-trifluoro-1-(methyl)ethylamine instead of ethanolamine, to the title compound (190 mg, 98%) which was obtained as a white solid. MS: m/e=424.0 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09073908B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-c26720c748a04c52a0c75f36bf137cc0 |
| 出典メモ | uspto-grants-2015_07 |