化工社化工社 化学情報印刷レポート · 研究参考用
Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 4,5-Dichloro-1,2-phenylenediamine | HCID 79297 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One | HCID 9899148 | 91.5% |
反応手順
To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CDI (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09073923B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-a35449cbef904f66a5d894eb6a8c4db4 |
| 出典メモ | uspto-grants-2015_07 |