N-Bromosuccinamide → 6-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one

HRID 1521658ノート

反応式

HRID 1521658 の反応式
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2.[Br:13]NC(=O)CCC(N)=O>CN(C)C=O>[Br:13][C:11]1[C:2]([F:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:12])[CH2:5][CH2:4]2

参加物

4

反応物 2

HCID 9834204N-BromosuccinamideHCID 227369425-Fluoro-3,4-dihydroquinolin-2(1H)-one

生成物 1

HCID 709801486-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 5-fluoro-3,4-dihydroquinolin-2(1H)-one (146-4; 0.45 g, 0.00272 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinamide (0.53 g, 0.0029 mol). Reaction mass was allowed to stir for overnight. Ice cold water was added to reaction mass. The solid separated was filtered and dried thoroughly to obtain the title compound. MS (M+1): 246.0.

後処理

  1. customReaction mass
  2. additionIce cold water was added to reaction mass
  3. customThe solid separated
  4. filtrationwas filtered
  5. customdried thoroughly

出典と根拠

ORDレコード
ord-80f57e261f5a44dcac8d28ddc0847a22
出典データセット
uspto-grants-2015_07
特許番号
US09073929B2

反応ノート

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