関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyruvic Acid | HCID 1060 | — |
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 2-Amino-6-chloro-3-iodopyridine | HCID 45480365 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Chloro-1H-pyrrolo(2,3-b)pyridine-2-carboxylic acid | HCID 21976580 | 194.8% |
反応手順
To a solution of 6-chloro-3-iodopyridin-2-amine (24 g, 94 mmol) in DMF is added DABCO (32 g, 283 mmol) and pyruvic acid (20 mL, 283 mmol). The mixture is degassed by bubbling argon gas through the mixture for 20 min. Pd(OAc)2 (1 g, 4.7 mmol) is added and the mixture is again degassed. The reaction mixture is heated at 110° C. for 3 h, and the solvent is evaporated to afford the title compound as a viscous liquid (36 g, >99%) which is used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09073926B2 |
|---|
| 出典データセット | uspto-grants-2015_07 |
|---|
| ORD ID | ord-99ed89870ee64cec90aa651c6f43d132 |
|---|
| 出典メモ | uspto-grants-2015_07 |
|---|
