Potassium Carbonate → 8,9-Dimethyl-6-oxo-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-a]pyrazine-2-carboxylic acid
反応式
[NH2:1][CH:2]([CH3:24])[CH:3]([N:5]1[C:9]2=[N:10][C:11]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:13]=[C:8]2[CH:7]=[C:6]1[C:19](OCC)=[O:20])[CH3:4].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:24][CH:2]1[CH:3]([CH3:4])[N:5]2[C:9]3[N:10]=[C:11]([C:14]([OH:16])=[O:15])[CH:12]=[CH:13][C:8]=3[CH:7]=[C:6]2[C:19](=[O:20])[NH:1]1参加物
4
実験手順
To a solution of diethyl 1-(3-aminobutan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2,6-dicarboxylate (3.83 g, 11.5 mmol) in ethanol (45 mL) is added potassium carbonate (4.76 g, 34.5 mmol). The mixture is stirred at room temperature for 64 h. The ethanol is removed in vacuo and the aqueous mixture is acidified to pH 6 with 1N aqueous HCl. The resulting solid is collected by filtration and dried in vacuo to afford the title compound as a white solid (2.00 g, 54%). LCMS: 260.67 (M+H+).