sodium (1Z)-1-cyanoprop-1-en-2-olate → (2E)-2-[(6-fluoro-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile
反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][C:3]=1[CH:11]=O.[C:13](/[CH:15]=[C:16](\[O-:18])/[CH3:17])#[N:14].[Na+]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][C:3]=1/[CH:11]=[C:15](/[C:16](=[O:18])[CH3:17])\[C:13]#[N:14]参加物
3
実験手順
The title compound was prepared from 3.7 g (80% purity, 18.0 mmol) 6-fluoro-1H-indazole-5-carbaldehyde (Example 12A) and 2.08 g (19.84 mmol) sodium (1Z)-1-cyanoprop-1-en-2-olate in analogy to the procedure described in Example 2A yielding 2.5 g (61% of th.) of product which was used in subsequent steps without further purification.
後処理
- customyielding 2.5 g (61% of th.) of product which
- customwas used in subsequent steps without further purification
出典と根拠
- ORDレコード
- ord-1064a9a146cf40ee9aa3b58bf350b400
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073939B2
反応ノート
読み込み中…