Methylhydrazine → 3'-Fluoro-6'-methyl-2,2'-bipyridin-4-amine
反応式
[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([N:15]3C(=O)C4C(=CC=CC=4)C3=O)[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.CNN>ClCCl>[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([NH2:15])[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1参加物
4
実験手順
2-(3′-fluoro-6′-methyl-2,2′-bipyridin-4-yl)isoindoline-1,3-dione (65 mg, 0.195 mmol) was suspended in dichloromethane (3 mL); methylhydrazine (0.205 mL, 3.90 mmol) was added and the mixture was stirred at room temperature over night. The reaction was filtered thru Celite® and the filtrate was concentrated to give the title compound as a clear yellow film which was used without further purification. ESI-MS: m/z 204.1 (M+H).
後処理
- filtrationThe reaction was filtered thru Celite®
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-7b73937650114c658fd548abc5249772
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073918B2
反応ノート
読み込み中…