(R)-(-)-2-Amino-1-propanol → HCID 86682888、化合物

反応式

[CH3:1][C@H:2]([CH2:7][C:8](OC)=O)[C:3](OC)=O.[NH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[CH3:1][C@@H:2]1[CH2:7][CH2:8][N:12]([C@H:13]([CH3:16])[CH2:14][OH:15])[CH2:3]1

参加物

反応物 2

HCID 80308(R)-(-)-2-Amino-1-propanol

HCID 9834036Dimethyl (R)-(+)-methylsuccinate

生成物 1

HCID 86682888HCID 86682888、化合物

実験手順

The title compound was synthesized as described in Intermediate 11 using (R)-dimethyl 2-methylsuccinate and (R)-2-aminopropan-1-ol as starting materials. 1H NMR (CDCl3): δ 3.57 (dd, 1H), 3.32 (dd, 1H), 3.02 (br s, 1H), 2.81 (dd, 1H), 2.69 (m, 2H), 2.60 (m, 1H), 2.20 (m, 1H), 2.12 (dd, 1H), 1.98 (m, 1H), 1.32 (m, 1H), 1.04 (m, 6H); MS: 144.3 (M+H)+.

出典と根拠

ORDレコード: ord-3289deeb79464d07b3554e519cf892f5
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09078871B2

反応ノート

読み込み中…

参加物