Triethylamine → N-methoxy-N-methyl-4-(pentafluoro-lambda6-sulfanyl)benzamide

反応式

[F:1][S:2]([F:15])([F:14])([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.Cl.[CH3:17][O:18][NH:19][CH3:20].C(N(CC)CC)C>ClCCl>[CH3:17][O:18][N:19]([CH3:20])[C:7](=[O:8])[C:6]1[CH:10]=[CH:11][C:3]([S:2]([F:15])([F:14])([F:13])([F:12])[F:1])=[CH:4][CH:5]=1

参加物

実験手順

4-(Pentafluoro-λ6-sulfanyl)benzoyl chloride (1.00 g, 3.751 mmol), O,N-dimethyl-hydroxylamine hydrochloride (0.402 g, 4.13 mmol), and triethylamine (0.835 g, 8.25 mmol) were stirred in dichloromethane for 2 hours at room temperature. The reaction was concentrated in vacuo and diethyl ether added. The solid was collected by filtration and purified by silica gel column chromatography to afford the title compound as a solid (0.557 g, 51% yield).