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Methyl 4-iodobenzoate → 1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-iodobenzoate | HCID 69273 | — |
| 反応物 | 4-Hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 68682215 | — |
| 反応物 | 1-Bromo-2-(4-chlorophenylsulfanyl)-5-(trifluoromethyl)benzene | HCID 68683413 | — |
| 生成物 | 1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol | HCID 68683807 | — |
反応手順
1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol (intermediate for 4a) was prepared from 4-hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester, and 4-iodo-benzoic acid methyl ester by the palladium-catalysed coupling procedure described for 1-bromo-2-(4-chloro-phenylsulfanyl)-5-(trifluoromethyl)-benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732463B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-e755c54ecda14b6e9ec408363ce84315 |
| 出典メモ | uspto-grants-2010_06 |