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HRID 1523705作成日：2026年10月27日
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide → 2-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]isoindole-1,3-dione
https://huagongshe.com/reaction/1523705
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (S)-(+)-N-(2,3-Epoxypropyl)phthalimide | HCID 719412 | — |
| 反応物 | Magnesium Chloride | HCID 5360315 | — |
| 反応物 | 4-(4-Isocyanatophenyl)morpholin-3-one | HCID 53341421 | — |
| 溶媒 | Isoamyl Acetate | HCID 31276 | — |
| 生成物 | 2-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]isoindole-1,3-dione | HCID 11690317 | 95.5% |
反応手順
(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.56 g, 22.46 mmol, 1.3 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in isoamyl acetate (70 mL) respectively, and heated to 120° C. Then magnesium chloride (0.12 g, 1.28 mmol) was added, the mixture was reacted for 4 h, white solid was obtained by filtration (6.97 g, yield: 95.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09079892B2 |
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| 出典データセット | uspto-grants-2015_07 |
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| ORD ID | ord-0b9f202109ab4ef4a6965f916852ec03 |
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| 出典メモ | uspto-grants-2015_07 |
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