5-Bromo-3-methylpyrazin-2-amine → HCID 90313024、化合物

HRID 1523954ノート

反応式

HRID 1523954 の反応式
Br[C:2]1[N:3]=[C:4]([CH3:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[F:10][C:11]1[CH:12]=[C:13]([C:26]2[C:27]([S:32]([NH:35][CH3:36])(=[O:34])=[O:33])=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:14]=[CH:15][C:16]=1B1OC(C)(C)C(C)(C)O1>>[NH2:8][C:5]1[N:6]=[CH:7][C:2]([C:16]2[CH:15]=[CH:14][C:13]([C:26]3[C:27]([S:32]([NH:35][CH3:36])(=[O:33])=[O:34])=[CH:28][CH:29]=[CH:30][CH:31]=3)=[CH:12][C:11]=2[F:10])=[N:3][C:4]=1[CH3:9]

参加物

3

反応物 2

HCID 217851475-Bromo-3-methylpyrazin-2-amineHCID 90313202HCID 90313202、化合物

生成物 1

HCID 90313024HCID 90313024、化合物

実験手順

The title compound was prepared in a manner similar to that described in Example 427 using 5-bromo-3-methylpyrazin-2-amine and 3′-fluoro-N-methyl-4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-2-sulfonamide. MS (ESI): mass calcd. for C18H17FN4O2S, 372.11; m/z found, 373.1 [M+H]+. 1H NMR (500 MHz, CD3OD) δ 8.27 (s, 1H), 8.09-8.00 (d, J=7.9, 1H), 7.96-7.87 (m, 1H), 7.71-7.63 (m, 1H), 7.63-7.55 (m, 1H), 7.44-7.38 (d, J=7.5, 1H), 7.34-7.21 (m, 2H), 2.46 (s, 3H), 2.44 (s, 3H).

出典と根拠

ORDレコード
ord-395b458dd35d4556a09efd69c61ab060
出典データセット
uspto-grants-2015_07
特許番号
US09079866B2

反応ノート

読み込み中…