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2-Chloro-6-methylnicotinic acid → 8-[1,2,3]Triazol-2-yl-naphthalene-1-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-6-methylnicotinic acid | HCID 121724 | — |
| 反応物 | 8-Bromonaphthalene-2-carboxylic acid | HCID 14696378 | — |
| 反応物 | 6-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid | HCID 67086855 | — |
| 生成物 | 8-[1,2,3]Triazol-2-yl-naphthalene-1-carboxylic acid | HCID 67116459 | — |
反応手順
The title compound was prepared in a manner analogous to Intermediate 70 substituting 8-bromo-2-napthoic acid for 2-chloro-6-methylnicotinic acid. The desired 8-[1,2,3]triazol-2-yl-naphthalene-1-carboxylic acid was obtained (474 mg, 16%). MS (ESI): mass calculated for C1H9N3O2, 239.20; m/z found 240.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.13 (t, J=9.0 Hz, 2H), 7.95-7.91 (m, 3H), 7.82 (dd, J=7.4, 1.0 Hz, 1H), 7.70 (dd, J=9.8, 5.8 Hz, 1H), 7.64-7.59 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09079911B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-45d55b7adadf46b6b5e7a288c76bbee1 |
| 出典メモ | uspto-grants-2015_07 |