2-Methoxybenzoic acid → (2-Methoxy-phenyl)-[5-(4-methyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone

反応式

[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:15][CH:14]3[CH:10]([CH2:11][NH:12][CH2:13]3)[CH2:9]2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](O)=[O:21]>>[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([N:12]1[CH2:13][CH:14]2[CH:10]([CH2:9][N:8]([C:4]3[N:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=3)[CH2:15]2)[CH2:11]1)=[O:21]

参加物

反応物 2

HCID 113702-Methoxybenzoic acid

HCID 644589662-(4-Methyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

生成物 1

HCID 67116351(2-Methoxy-phenyl)-[5-(4-methyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone

実験手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 27 and 2-methoxybenzoic acid. MS (ESI): mass calculated for C19H22N4O2, 338.41; m/z found 339.3 [M+H]+.

出典と根拠

ORDレコード: ord-bd20349c03ef467cb22eb7161da4dcde
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09079911B2

反応ノート

読み込み中…