1,4-Dioxane hydrochloride → Ethyl 4-((R)-amino(phenyl)methyl)phenyl(methyl)phosphinate hydrochloride
反応式
CC(C)([S@]([NH:6][C@H:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:8]1[CH:13]=[CH:12][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:10][CH:9]=1)=O)C.[ClH:27].O1CCOCC1>>[ClH:27].[NH2:6][C@H:7]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:8]1[CH:9]=[CH:10][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:12][CH:13]=1参加物
3
実験手順
Ethyl 4-((R)—((R)-1,1-dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate, 23-b, (9.5 g, 24.1 mmol) was dissolved in HCl/dioxane (100 ml) and the mixture was stirred at room temperature overnight. Then it was concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 23-c, (7.16 g, 91%).
後処理
- concentrationThen it was concentrated under vacuum