Diethyl (ethoxymethylene)malonate → Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate
反応式
Cl.[F:2][C:3]1[CH:4]=[N:5][N:6]([C:8]([NH2:10])=[NH:9])[CH:7]=1.C[O-].[Na+].C([O:16][CH:17]=[C:18]([C:24](OCC)=O)[C:19]([O:21][CH2:22][CH3:23])=[O:20])C>CCO>[F:2][C:3]1[CH:4]=[N:5][N:6]([C:8]2[N:10]=[C:17]([OH:16])[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:24][N:9]=2)[CH:7]=1参加物
5
実験手順
To a solution of 28-e (2 g, 12 mmol) in EtOH was added sodium methoxide (1 g, 18 mmol) and diethyl ethoxymethylenemalonate (2.64 g, 12 mmol). The reaction was cooled to room temperature, filtered and washed with EtOH and Et2O to afford the title product, 28-f, (1.9 g, 61%).
後処理
- filtrationfiltered
- washwashed with EtOH and Et2O
出典と根拠
- ORDレコード
- ord-93c23eec8f9a4e058021c389330afec4
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09079930B2
反応ノート
読み込み中…