Potassium Hydroxide → HCID 178524763、化合物
反応式
[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([O:16]CC)=[O:15])=[CH:9][N:8]=2)[CH:6]=1.[OH-].[K+]>CCO.O>[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([OH:16])=[O:15])=[CH:9][N:8]=2)[CH:6]=1参加物
5
反応条件
- 温度
- 78 °C
実験手順
Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate, 28-f, (1 g, 3.9 mmol) was dissolved in EtOH (7 mL) and KOH (0.67 g, 11.9 mmol) in H2O (3 mL) was added. The mixture was stirred at 78° C. for 1.5 h. Then the solvent was evaporated, and the residue was added about 10 mL of H2O and filtered. The solid was dried and washed by EtOH (5 mL) to give the title product, 28-g, (0.7 g).
後処理
- customThen the solvent was evaporated
- additionthe residue was added about 10 mL of H2O
- filtrationfiltered
- customThe solid was dried
- washwashed by EtOH (5 mL)
出典と根拠
- ORDレコード
- ord-abf3df972ba24d85b74d26bf5cf05d34
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09079930B2
反応ノート
読み込み中…