Methanol → HCID 57265114、化合物
反応式
[CH3:1][C:2]([CH3:16])([CH3:15])[CH2:3][CH:4]([C:10]([O:12]CC)=[O:11])[C:5]([O:7]CC)=[O:6].CO.[OH-].[K+].C1(C)C=CC=CC=1>O>[CH3:1][C:2]([CH3:16])([CH3:15])[CH2:3][CH:4]([C:5]([OH:7])=[O:6])[C:10]([OH:12])=[O:11]参加物
6
実験手順
To a solution of the above-obtained diethyl (2,2-dimethylpropyl)malonate on 500 cm3 of methanol a solution of 125 g of KOH in 1000 cm3 of water was added. The obtained mixture was refluxed for 5 h, and then methanol and ethanol were distilled off at atmospheric pressure. To the residue ca. 3000 cm3 of water was added, the obtained solution was acidified by saturated HCl to pH 1. The formed product was extracted with 3×500 ml of ether. To the combined extract 200 ml of toluene was added, and the obtained solution was evaporated in vacuum to give a ca. 3 to 1 mixture of the title product and toluene (on the evidence of NMR spectroscopy). This mixture was further used without an additional purification.