Hydrochloride methanol → 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

HRID 1525811ノート

反応式

HRID 1525811 の反応式
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:2].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:35](=[O:36])[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28]2=[O:37])[C:21]1=[O:38].[ClH:39].CO>C(Cl)Cl>[ClH:39].[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:16].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:28](=[O:37])[C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:35]2=[O:36])[C:21]1=[O:38]

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 710827862-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate

生成物 1

HCID 866187522-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The compound (76 mg) obtained from example 6 was dissolved in DCM (10 mL) and 15% HCl/methanol solution (5 mL) were added dropwise. The solvent was eliminated by rotary evaporation in vacuo and then white solid (82 mg) was obtained.

後処理

  1. customThe solvent was eliminated by rotary evaporation in vacuo

出典と根拠

ORDレコード
ord-45671870be1d4665bec8b305410ff9c0
出典データセット
uspto-grants-2015_07
特許番号
US09085563B2

反応ノート

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