Sodium Bicarbonate → HCID 53885254、化合物
反応式
Cl.[CH2:2]([O:4][C:5]([C:7]1([C:20]([O:22][CH2:23][CH3:24])=[O:21])[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH2:19])[CH3:18])=[CH:15][C:9]=2[O:8]1)=[O:6])[CH3:3].C(=O)([O-])O.[Na+]>ClCCl>[NH2:19][C@H:17]([CH3:18])[CH2:16][C:14]1[CH:13]=[CH:12][C:10]2[O:11][C:7]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([C:5]([O:4][CH2:2][CH3:3])=[O:6])[O:8][C:9]=2[CH:15]=1参加物
4
実験手順
A solution of (R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride (646 mg, 2 mMol) in dichloromethane (80 ml) was shaken with a saturated solution of sodium hydrogen carbonate (20 ml) for 30 seconds. The organic layer was separated and the aqueous layer was extracted with dichloromethane (2×50 ml). The combined organic extracts were washed with water (50 ml) and brine (50 ml), dried (MgSO4). The solvent was evaporated giving the title compound which was used immediately.