Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526522ノート

反応式

HRID 1526522 の反応式
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

参加物

4

反応物 2

HCID 313Hydrochloric Acid2 回HCID 22024915Icotinib

生成物 1

HCID 44609731Icotinib Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Icotinib (700 mg) and methanol (40 mL) were added into 100 mL of reaction flask, hydrogen chloride gas or concentrated hydrochloric acid was added while stirring. After its completion, the reaction mixture was filtrated to give crude products of Icotinib hydrochloride, which was then purified by recrystallization with isopropanol to give Icotinib hydrochloride (760 mg).

後処理

  1. additionwas added
  2. filtrationAfter its completion, the reaction mixture was filtrated

出典と根拠

ORDレコード
ord-fff8d148ae044b9fbaad1d3724758ee0
出典データセット
uspto-grants-2015_07
特許番号
US09085588B2

反応ノート

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