Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526523ノート

反応式

HRID 1526523 の反応式
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>C(O)C>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

生成物 1

HCID 44609731Icotinib Hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Icotinib (500 mg) was added into 100 mL of reaction flask and dissolved with 30 mL of ethanol. Hydrogen chloride gas was added while stirring. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (515 mg).

後処理

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

出典と根拠

ORDレコード
ord-80da284135314baea98d6d3c9585b5af
出典データセット
uspto-grants-2015_07
特許番号
US09085588B2

反応ノート

読み込み中…