Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526525ノート

反応式

HRID 1526525 の反応式
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>C(O)(C)C>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

生成物 1

HCID 44609731Icotinib Hydrochloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Icotinib (5 00 mg) was added into 100 mL of reaction flask and dissolved with 50 mL of isopropyl alcohol. Hydrogen chloride gas was added while stirring. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (500 mg).

後処理

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

出典と根拠

ORDレコード
ord-2eb7814b1cc14b279a9e33c6b8f8a751
出典データセット
uspto-grants-2015_07
特許番号
US09085588B2

反応ノート

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