Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526526ノート

反応式

HRID 1526526 の反応式
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

生成物 1

HCID 44609731Icotinib Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Icotinib (1000 mg) was added into 100 mL reaction flask and dissolved with 60 mL of methanol. The concentrated hydrochloric acid was added dropwise while stirring till PH was adjusted to 2.0. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (1000 mg).

後処理

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

出典と根拠

ORDレコード
ord-9e49f2bbef784368a34c6fcfab3981dd
出典データセット
uspto-grants-2015_07
特許番号
US09085588B2

反応ノート

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