Malonic Acid → 3-Amino-3-(3,5-di-tert-butylphenyl)propionic acid
反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:12]=1)[CH:8]=O)([CH3:4])([CH3:3])[CH3:2].[C:17]([OH:23])(=[O:22])[CH2:18]C(O)=O.C([O-])(=O)C.[NH4+:28]>C(O)(C)C>[NH2:28][CH:8]([C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:10]=1)[CH2:18][C:17]([OH:23])=[O:22]参加物
5
実験手順
A mixture 3,5-di-tert-butylbenzaldehyde (0.996 g, 4.56 mmol), malonic acid (0.572 g, 5.50 mmol) and ammonium acetate (0.710 g, 9.21 mmol) in isopropanol (30 mL) was heated at reflux under nitrogen for 5 h to afford a colorless solid. The solid was filtered and washed with hot isopropanol (30 mL). The residue was dried in vacuo to give the desired racemic product as a colorless solid (0.340 g).