methyl 2-(5-methoxy-1H-indol-3-yl)acetate → (1-Carbamoyl-5-methoxy-1H-indol-3-yl)-acetic acid

HRID 1527202

反応式

HRID 1527202 の反応式
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[NH:7][CH:6]=1.[C:17](N1C2C(=CC=CC=2)C(CC(O)=O)=C1)(=[O:19])[NH2:18]>>[C:17]([N:7]1[C:8]2[C:13](=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)[C:5]([CH2:4][C:3]([OH:2])=[O:16])=[CH:6]1)(=[O:19])[NH2:18]

参加物

3

反応物 2

HCID 594955methyl 2-(5-methoxy-1H-indol-3-yl)acetateHCID 68283440(1-Carbamoyl-1H-indol-3-yl)-acetic acid

生成物 1

HCID 68284249(1-Carbamoyl-5-methoxy-1H-indol-3-yl)-acetic acid

実験手順

was prepared from 5-methoxy-3-indolylacetic acid methyl ester according to the protocol described scheme A8 for the preparation of (1-carbamoyl-1H-indol-3-yl)-acetic acid. Rf, TLC (EtOAC)=0.2; MS (LC/MS): 248.9 [M+H]+, 271.0 [M+Na]+, 247.1 [M−H]−, 495.1 [2M−H]−, 204.1 [M−CONH2]−; tR (HPLC conditions f): 1.54 min.

後処理

  1. custom1.54 min.

出典と根拠

ORDレコード
ord-a20b10136a7e4a17973722a0388f08a9
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

関連ノート

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