1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one → HCID 68283797、化合物
反応式
[C:1]([C:4]1[C:12]2[C:7](=C[CH:9]=[C:10](OC(F)(F)F)[CH:11]=2)[N:6]([CH2:18][C:19]([OH:21])=[O:20])[CH:5]=1)(=[O:3])[CH3:2].[NH:22]1C2=NC=CC=C2C(C(=O)C)=C1>>[C:1]([C:4]1[C:12]2[C:7](=[N:22][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:18][C:19]([OH:21])=[O:20])[CH:5]=1)(=[O:3])[CH3:2]参加物
3
実験手順
was prepared in a similar manner as described in step B and C of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid from 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanone [83393-46-8]. MS (UPLC/MS): 219.2 [M+H]+, 217.2 [M−H]−, 263.3 [M+HCOO]−, 435.3 [2M−H]−; tR (HPLC conditions f): 1.16 min. 1H-NMR (400 MHz, DMSO): δ (ppm): 8.55 (bs, 1H), 8.49 (dd, 1H), 8.36 (dd, 1H), 7.31 (dd, 1H), 5.12 (s, 2H), 2.48 (s, 3H).
後処理
- customwas prepared in a similar manner
- custom1.16 min
出典と根拠
- ORDレコード
- ord-488d59f0bf0549e8aaec946dd6c81946
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09085555B2
反応ノート
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