Cesium carbonate → [3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-yl)-benzyl]-carbamic acid tert-butyl ester

反応式

[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][C:9]1[CH:14]=[C:13](Br)[CH:12]=[C:11]([Cl:16])[C:10]=1[F:17])([CH3:4])([CH3:3])[CH3:2].CO[N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.[C:27](=O)([O-])[O-:28].[Cs+].[Cs+].C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([N:21]2[CH2:22][CH2:23][CH:24]([O:28][CH3:27])[CH2:25][CH2:26]2)[CH:12]=[C:11]([Cl:16])[C:10]=1[F:17])([CH3:4])([CH3:3])[CH3:2]