(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid → (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-propylpropenoic acid

HRID 1527691ノート

反応式

HRID 1527691 の反応式
[Br:1][C:2]1[C:3](/[CH:16]=[C:17](\[CH2:23][CH2:24][CH3:25])/[C:18]([O:20]CC)=[O:19])=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.COC1C2C(=CC=CC=2)C(OC)=CC=1/C=C(\C)/C(O)=O>CCOC(C)=O>[Br:1][C:2]1[C:3](/[CH:16]=[C:17](\[CH2:23][CH2:24][CH3:25])/[C:18]([OH:20])=[O:19])=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

4

反応物 2

HCID 46180242(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acidHCID 86647737Ethyl (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-propylpropenoate

生成物 1

HCID 68770455(E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-propylpropenoic acid

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Compound 99f was prepared from 98f (0.177 g, 0.435 mmol) as described above for 29a to give 0.078 g (0.21 mmol, 47%) of the product as a white solid following flash chromatography (1:3 EtOAc:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

後処理

  1. customto give

出典と根拠

ORDレコード
ord-3ac4216391c342dfa4ca70857b2556a5
出典データセット
uspto-grants-2015_07
特許番号
US09089605B2

反応ノート

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